Randomized phase III study of whole-brain radiotherapy for primary CNS lymphoma
نویسندگان
چکیده
منابع مشابه
Journal Club: Randomized phase III study of whole-brain radiotherapy for primary CNS lymphoma.
OBJECTIVE This is the final report of a phase III randomized study to evaluate whole-brain radiotherapy (WBRT) in primary therapy of primary CNS lymphoma (PCNSL) after a median follow-up of 81.2 months. METHODS Patients with newly diagnosed PCNSL were randomized to high-dose methotrexate (HDMTX)-based chemotherapy alone or followed by WBRT. We hypothesized that the omission of WBRT would not ...
متن کاملCombined immunochemotherapy with reduced whole-brain radiotherapy for newly diagnosed primary CNS lymphoma.
PURPOSE Our goals were to evaluate the safety of adding rituximab to methotrexate (MTX)-based chemotherapy for primary CNS lymphoma, determine whether additional cycles of induction chemotherapy improve the complete response (CR) rate, and examine effectiveness and toxicity of reduced-dose whole-brain radiotherapy (WBRT) after CR. PATIENTS AND METHODS Thirty patients (17 women; median age, 57...
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Department of Hematology, Oncology and Palliative Care, Klinikum Stuttgart, Stuttgart, Germany; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA; Unit of Lymphoid Malignancies, Department of Onco-Hematology, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy; Division of Hematology/Oncology, San Francisco Helen Diller ...
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BACKGROUND While there has been significant progress in outcomes for patients diagnosed with primary central nervous system (CNS) lymphoma (PCNSL), survival rates will likely plateau with the current armamentarium of agents used to treat these patients. Moreover, given that PCNSL increasingly impacts an older population, a significant proportion of patients are not eligible for intensive therap...
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To estimate the value of whole brain radiotherapy (WBRT) in the treatment of primary CNS lymphoma (PCNSL), it is important to recall the goals of treatment when confronted with this disease. Presumably, our goals of PCNSL treatment are to improve neurological deficits, improve or maintain quality of life, delay neurological progression, prolong progression-free survival, prolong overall surviva...
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ژورنال
عنوان ژورنال: Neurology
سال: 2015
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0000000000001395